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Metastasis

MedGen UID:
45032
Concept ID:
C0027627
Neoplastic Process
Synonyms: Metastase; Metastases; Metastases, Neoplasm; Metastasis, Neoplasm; Neoplasm Metastases; Neoplasm Metastasis

Definition

The spread or migration of cancer cells from one part of the body (the organ in which it first appeared) to another. The secondary tumor contains cells that are like those in the original (primary) tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastasis

Professional guidelines

PubMed

Devaud N, Vornicova O, Abdul Razak AR, Khalili K, Demicco EG, Mitric C, Bernardini MQ, Gladdy RA
Surg Oncol Clin N Am 2022 Jul;31(3):527-546. doi: 10.1016/j.soc.2022.03.011. PMID: 35715148
Davis LE, Shalin SC, Tackett AJ
Cancer Biol Ther 2019;20(11):1366-1379. Epub 2019 Aug 1 doi: 10.1080/15384047.2019.1640032. PMID: 31366280Free PMC Article
Ferguson JL, Turner SP
Am Fam Physician 2018 Aug 15;98(4):205-213. PMID: 30215968

Recent clinical studies

Etiology

Tsukamoto S, Kido A, Tanaka Y, Facchini G, Peta G, Rossi G, Mavrogenis AF
Curr Oncol 2021 Aug 29;28(5):3347-3372. doi: 10.3390/curroncol28050290. PMID: 34590591Free PMC Article
Sobierajska K, Ciszewski WM, Sacewicz-Hofman I, Niewiarowska J
Adv Exp Med Biol 2020;1234:71-86. doi: 10.1007/978-3-030-37184-5_6. PMID: 32040856
Martin OA, Anderson RL
Clin Exp Metastasis 2018 Apr;35(4):219-221. Epub 2018 Jul 3 doi: 10.1007/s10585-018-9914-x. PMID: 29971590
Huang D, Sun W, Zhou Y, Li P, Chen F, Chen H, Xia D, Xu E, Lai M, Wu Y, Zhang H
Cancer Metastasis Rev 2018 Mar;37(1):173-187. doi: 10.1007/s10555-017-9726-5. PMID: 29322354
Steeg PS
Nat Rev Cancer 2016 Apr;16(4):201-18. doi: 10.1038/nrc.2016.25. PMID: 27009393Free PMC Article

Diagnosis

Wang Y, Yang W, Wang Q, Zhou Y
Front Immunol 2023;14:1206504. Epub 2023 Jun 8 doi: 10.3389/fimmu.2023.1206504. PMID: 37359527Free PMC Article
Park M, Kim D, Ko S, Kim A, Mo K, Yoon H
Int J Mol Sci 2022 Jun 18;23(12) doi: 10.3390/ijms23126806. PMID: 35743249Free PMC Article
Ko J, Winslow MM, Sage J
EMBO Mol Med 2021 Jan 11;13(1):e13122. Epub 2020 Dec 9 doi: 10.15252/emmm.202013122. PMID: 33296145Free PMC Article
Mittal V
Annu Rev Pathol 2018 Jan 24;13:395-412. doi: 10.1146/annurev-pathol-020117-043854. PMID: 29414248
Weigelt B, Peterse JL, van 't Veer LJ
Nat Rev Cancer 2005 Aug;5(8):591-602. doi: 10.1038/nrc1670. PMID: 16056258

Therapy

Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Abba ML, Patil N, Leupold JH, Saeed MEM, Efferth T, Allgayer H
Cancer Lett 2018 Aug 10;429:11-18. Epub 2018 May 8 doi: 10.1016/j.canlet.2018.05.008. PMID: 29746932
Ferrarotto R, Redman MW, Gandara DR, Herbst RS, Papadimitrakopoulou VA
Chin Clin Oncol 2015 Sep;4(3):36. doi: 10.3978/j.issn.2304-3865.2015.09.02. PMID: 26408303
Hersey P, Gallagher S
J Surg Oncol 2014 Mar;109(4):320-6. Epub 2013 Dec 3 doi: 10.1002/jso.23494. PMID: 24301265
Galsky MD, Hahn NM, Rosenberg J, Sonpavde G, Hutson T, Oh WK, Dreicer R, Vogelzang N, Sternberg CN, Bajorin DF, Bellmunt J
J Clin Oncol 2011 Jun 10;29(17):2432-8. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.8433. PMID: 21555688

Prognosis

Zaorsky NG, Wang X, Garrett SM, Lehrer EJ, Lin C, DeGraff DJ, Spratt DE, Trifiletti DM, Kishan AU, Showalter TN, Park HS, Yang JT, Chinchilli VM, Wang M
Int J Cancer 2022 Jan 1;150(1):132-141. Epub 2021 Aug 27 doi: 10.1002/ijc.33744. PMID: 34287840Free PMC Article
Tanaka A, Katagiri H, Murata H, Wasa J, Miyagi M, Honda Y, Takahashi M
Bone Joint J 2020 Mar;102-B(3):285-292. doi: 10.1302/0301-620X.102B3.BJJ-2019-0976.R1. PMID: 32114815
Guo J, Zhao J, Bi X, Li Z, Huang Z, Zhang Y, Cai J, Zhao H
Oncotarget 2017 May 23;8(21):35368-35375. doi: 10.18632/oncotarget.15685. PMID: 28430639Free PMC Article
Dominguez-Ventura A, Nichols FC 3rd
Thorac Surg Clin 2006 May;16(2):139-43. doi: 10.1016/j.thorsurg.2005.12.001. PMID: 16805203
Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E
N Engl J Med 2002 Oct 17;347(16):1227-32. doi: 10.1056/NEJMoa020989. PMID: 12393819

Clinical prediction guides

Rehman AH, Jones RP, Poston G
Eur J Surg Oncol 2019 Dec;45(12):2251-2256. Epub 2019 Jun 27 doi: 10.1016/j.ejso.2019.06.038. PMID: 31279594
Arana E, Kovacs FM, Royuela A, Asenjo B, Pérez-Ramírez Ú, Zamora J; Spanish Back Pain Research Network Task Force for the Improvement of Inter-Disciplinary Management of Spinal Metastasis
J Natl Compr Canc Netw 2016 Jan;14(1):70-6. Epub 2016 Jan 5 doi: 10.6004/jnccn.2016.0008. PMID: 26733556
O'Flaherty JD, Gray S, Richard D, Fennell D, O'Leary JJ, Blackhall FH, O'Byrne KJ
Lung Cancer 2012 Apr;76(1):19-25. Epub 2011 Dec 29 doi: 10.1016/j.lungcan.2011.10.018. PMID: 22209049
Edge SB, Compton CC
Ann Surg Oncol 2010 Jun;17(6):1471-4. doi: 10.1245/s10434-010-0985-4. PMID: 20180029
Förster Y, Meye A, Albrecht S, Schwenzer B
Clin Chim Acta 2006 Feb;364(1-2):12-21. Epub 2005 Sep 2 doi: 10.1016/j.cca.2005.05.018. PMID: 16139825

Recent systematic reviews

Gao X, Yang Y, Wang Y, Huang Y
Int J Hyperthermia 2023 Dec;40(1):2244713. doi: 10.1080/02656736.2023.2244713. PMID: 37604507
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
Li Y, Liu Y, Liang Y, Wei R, Zhang W, Yao W, Luo S, Pang X, Wang Y, Jiang X, Lai S, Yang R
Eur Radiol 2022 Nov;32(11):8039-8051. Epub 2022 May 19 doi: 10.1007/s00330-022-08828-x. PMID: 35587827
Xu W, He Y, Wang Y, Li X, Young J, Ioannidis JPA, Dunlop MG, Theodoratou E
BMC Med 2020 Jun 26;18(1):172. doi: 10.1186/s12916-020-01618-6. PMID: 32586325Free PMC Article
Lievens Y, Guckenberger M, Gomez D, Hoyer M, Iyengar P, Kindts I, Méndez Romero A, Nevens D, Palma D, Park C, Ricardi U, Scorsetti M, Yu J, Woodward WA
Radiother Oncol 2020 Jul;148:157-166. Epub 2020 Apr 22 doi: 10.1016/j.radonc.2020.04.003. PMID: 32388150

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